尤伟婷,但卫华,但年华,梁永贤,刘博文,温会涛
YOU Weiting,DAN Weihua,DAN Nianhua,LIANG Yongxian,LIU Bowen,WEN Huitao

• 1:四川大学制革清洁技术国家工程实验室
• 2:四川大学生物医学工程技术研究中心
• 3:兴业皮革科技股份有限公司

摘要(Abstract)：

以海藻酸钠为原料、高碘酸钠为氧化剂制备氧化海藻酸钠,考察氧化海藻酸钠改性胶原膜后对其机械强度、湿热稳定性、生物相容性和降解性的影响,对不同浓度氧化海藻酸钠修饰改性胶原膜形成的膜材料进行研究。结果发现:经过氧化海藻酸钠修饰改性后,胶原保持完整的三股螺旋结构,膜材料的机械强度、湿热稳定性和降解性均得到提高,表现出良好的细胞相容性,有望用做可控降解胶原基支架材料。
The oxidation sodium alginate was prepared by using sodium alginate as raw material,and sodium periodate as oxidant. The mechanical strength,hydrothermal stability,degradation property and biocompatibility of the collagen film modified by oxidation sodium alginate were studied. The collagen film materials modified with different concentrations oxidation sodium alginate were researched. Results show that the natural triple helix structure of collagen isn't destroyed by oxidation sodium alginate. The mechanical strength,hydrothermal stability and degradation property of the collagen films are enhanced after modification,and have good cytocompatibility. The modified collagen films are expected to serve as a kind of controllable degradation collagen-based scaffold material.

关键词(KeyWords)： 胶原膜;氧化海藻酸钠;改性;支架材料;降解
collagen film;oxidation sodium alginate;modification;scaffold material;degradation

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(51473001)

作者(Author): 尤伟婷,但卫华,但年华,梁永贤,刘博文,温会涛
YOU Weiting,DAN Weihua,DAN Nianhua,LIANG Yongxian,LIU Bowen,WEN Huitao

DOI: 10.13536/j.cnki.issn1001-6813.2017-008-004

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